Figure 3.

NAD⁺ administration profoundly attenuated both UVC-induced skin damage and UVC-induced increases in the green AF of the skin of mice. A, B. NAD⁺ administration significantly decreased UVC-induced skin damage. N = 3. ***, P < 0.001. Scale bar = 100 μm. C, D. NAD⁺ administration significantly attenuated UVC-induced increases in the green AF intensity of the mice’s skin. After the mice were administered with 1 mg/kg NAD⁺, the mice were exposed to UVC irradiation at the dosages of 0.6 J/cm². Three days after the irradiation, the skin’s damage was determined by H&E staining. The skin’s green AF was determined under a confocal microscope. N = 10. ***, P < 0.001. Scale bar = 20 μm.