Figure 7.

NAD⁺ administration significantly attenuated UVC-induced increases in the Bcl-2/Bax ratios of the skin of mice. A, B. UVC induced significant decreases in the levels of Bcl-2, which were prevented by NAD⁺ pre-treatment. A, C. UVC did not significantly affect the levels of Bax, which were not affected by NAD⁺ pre-administration. D. UVC induced significant decreases in the Bcl-2/Bax ratios, which were prevented by NAD⁺ administration. After the mice were administered with 1 mg/kg NAD⁺, the mice were exposed to UVC irradiation at the dosages of 0.6 J/cm². One hr after the irradiation, the levels of Bcl-2 and Bax of the skin were determined by Western blot assays. N = 6; *, P < 0.05.