Table 4.

Cost of current treatment

Drug/treatment	MOA	USD
Hydroxyurea	Increase HbF	16,800
L-glutamine	Decreased oxidation	36,000
Crizanlizumab	P-seletin binding	100,000
Voxelotor	Decreased hemolysis	125,000
RBC exchange	Non-SS RBCs	3,000*
Allo-transplant	Corrected source	145,000^
Gene therapy	BCL11A disruption	2,700,000^
Gene therapy	CRISPR correct globin	>2,000,000^

^*This is cost per event not per year, RBC exchange may be monthly.

^{^}This is one time only cost.