Table 2.
Adjusted hazards ratios (HR) and 95 % CI for the risk of the conversion from metabolically healthy to unhealthy phenotype, across different BMI and high-sensitivity C-reactive protein (hs-CRP) groups during 5 years of follow-up among 4855 metabolically healthy Chinese adults
| Baseline BMI | – | Normal (<24·0 kg/m2) | Overweight (≥24·0 kg/m2) | Per unit of BMI | P for linear trend | ||
|---|---|---|---|---|---|---|---|
| HR | 95 % CI | HR | 95 % CI | ||||
| Sample number | 3806 | 1049 | – | – | |||
| Case number | 1150 | 542 | – | – | |||
| Model 1* | Ref. (1) | 1·66 | 1·46, 1·80 | 1·13 | 1·10, 1·16 | <0·001 | |
| Model 2† | Ref. (1) | 1·19 | 1·07, 1·33 | 1·04 | 1·02, 1·07 | 0·002 | |
| Model 3‡ | Ref. (1) | 1·16 | 1·04, 1·30 | 1·04 | 1·01, 1·07 | 0·008 | |
| Baseline hs-CRP | – | Low risk (<1 mg/l) | High risk (≥1 mg/l) | – | – | ||
| Sample number | 3987 | 868 | – | – | |||
| Case number | 1300 | 392 | – | – | |||
| Model 1* | Ref. (1) | 1·40 | 1·25, 1·57 | 1·3 | 1·19, 1·41 | <0·001 | |
| Model 2† | Ref. (1) | 1·15 | 1·03, 1·29 | 1·12 | 1·02, 1·22 | 0·017 | |
| Model 3‡ | Ref. (1) | 1·11 | 0·99, 1·25 | 1·09 | 0·99, 1·19 | 0·074 | |
Model 1, adjusting for age (years) and sex.
Model 2, adjusting for age (years) and sex, and further baseline systolic blood pressure (mmHg), diastolic blood pressure (mmHg), fasting blood glucose (mmol/l), HbA1c (%), total cholesterol (mmol/l), TAG (mmol/l), LDL-cholesterol (mmol/l), HDL-cholesterol (mmol/l), alanine transferase (U/l), aspartate transferase (U/l), uric acid (μmol/l) and estimating glomerular filtration rate (ml/min per 1·73 m2).
Model 3, adjusting for variables in model 2 and further baseline hs-CRP (mg/l) for BMI as well as BMI (kg/m2) for hs-CRP.