Table 2.

Challenges in the implementation of human rabies treatment

Number	Challenges
1	Historical fear and ignorance of a virulent pathogen
2	Extensive CNS involvement by time of diagnostic suspicion
3	Not an outpatient option
4	Unvaccinated healthcare workers
5	Need for a ‘dream team’ of intensive care specialists
6	Dedicated intensive care facility
7	No licensed antiviral drugs, requiring heroic use
8	Uncertain pathobiological targets and mechanisms
9	Delivery of biologics across the BBB
10	Clinical and diagnostic difficulties in monitoring patient status
11	Costs of therapy
12	Extensive rehabilitation
13	Quality of life in the face of neurological deficits
14	Religious, cultural, and ethical concerns on ‘experimentation’
15	High probability of failure