Extended Data Fig. 5. mtDNA off-target editing by the lead MitoKO DdCBE pairs following high level expression.
a,b. Mitochondrial genome-wide off-targeting of the lead MitoKO DdCBE pairs (Fig. 3) measured by NGS 14 days after transfection and presented as absolute values (a) or fold change over wild-type (WT) controls (b). Bars represent the mean and error bars represent ± SEM (n = 3, technical replicates). Source data are provided as a Source Data file. c. On-target (Y axis) vs. off-target (X axis) for the lead MitoKO DdCBE pairs. Dots represent the mean (n = 3, technical replicates). Source data are provided as a Source Data file.