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. 2023 May 18;14:2844. doi: 10.1038/s41467-023-38602-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Multiple linear regression models adjusted for: all image-related confounds, age, age², sex, educational qualifications, Townsend Deprivation Index, household income, historical job code, waist-hip-ratio, alcohol intake, smoking status, diuretic use. Multiple comparison correction: blue line represents False Discovery Rate (FDR) two-sided P value threshold (5%) = 9.58 × 10⁻³, red line represents Bonferroni threshold on 2138 tests = 2.34 × 10⁻⁵). Source data are provided as a Source Data file.