Table 3.
Change in COMPASS scores from baseline at day 42 for memory, accuracy, focus and concentration, and learning for Neuriva® and placebo in the PP population (n = 128)
| Task | Neuriva® (n = 64) Mean ± SD Within-group P value |
Placebo (n = 64) Mean ± SD Within-group P value |
|---|---|---|
| Choice reaction time (focus and concentration) | ||
| Reaction time: correct (ms) |
− 388.8 ± 591.1 < 0.001 |
− 382.5 ± 584.0 < 0.001 |
| Digit vigilance (accuracy, focus and concentration) | ||
| Accuracy: overall (%) |
7.0 ± 13.9 < 0.001 |
4.1 ± 13.3 0.049 |
| False alarm (count) |
− 1.1 ± 2.9 0.003 |
− 1.2 ± 2.1 < 0.001 |
| Numeric working memory (memory, accuracy*, focus and concentration) | ||
| Accuracy: overall (%) |
5.6 ± 9.7 < 0.001 |
2.0 ± 8.8 0.219 |
| Accuracy: yes (%) |
8.1 ± 13.5 < 0.001 |
3.1 ± 12.8 0.096 |
| Reaction time: correct (ms) |
− 314.8 ± 402.7 < 0.001 |
− 170.7 ± 376.7 0.001 |
| Reaction time: no (ms) |
− 280.1 ± 497.3 < 0.001 |
− 220.3 ± 448.5 < 0.001 |
| Reaction time: yes (ms) |
− 341.9 ± 393.5 < 0.001 |
− 166.8 ± 388.0 0.006 |
| Computerized Corsi blocks (memory, accuracy, focus and concentration) | ||
| Span score |
0.4 ± 1.4 0.033 |
0.5 ± 1.3 0.003 |
| Picture recognition (memory, accuracy*, learning) | ||
| Accuracy: overall (%) |
1.5 ± 6.2 0.012 |
0.1 ± 2.6 0.994 |
| Accuracy: yes (%) |
1.9 ± 8.2 0.022 |
0.2 ± 4.4 0.952 |
| Reaction time: overall (ms) |
− 217.6 ± 390.3 < 0.001 |
− 140.6 ± 240.2 0.001 |
| Reaction time: correct (ms) |
− 206.0 ± 370.5 < 0.001 |
− 144.3 ± 231.1 < 0.001 |
| Reaction time: no (ms) |
− 167.8 ± 332.1 < 0.001 |
− 155.4 ± 253.8 < 0.001 |
| Reaction time: yes (ms) |
− 267.4 ± 495.1 < 0.001 |
− 125.8 ± 264.9 0.095 |
| Word recognition (memory, accuracy*, learning) | ||
| Accuracy: yes (%) |
5.4 ± 15.3 0.012 |
1.5 ± 16.1 0.716 |
| Reaction time: overall (ms) |
− 179.6 ± 303.8 < 0.001 |
− 192.2 ± 453.6 < 0.001 |
| Reaction time: correct (ms) |
− 156.3 ± 294.6 < 0.001 |
− 187.1 ± 427.1 < 0.001 |
| Reaction time: no (ms) |
− 130.9 ± 372.3 0.020 |
− 144.0 ± 474.1 0.009 |
| Reaction time: yes (ms) |
− 228.3 ± 419.7 < 0.001 |
− 240.4 ± 519.9 < 0.001 |
*Accuracy was assessed by accuracy outcomes only
ms milliseconds, n number, SD standard deviation
Within-group changes were evaluated using a paired t test with p < 0.05 considered statistically significant
Data not shown for non-significant within group changes