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. 2023 May 5;14:1155271. doi: 10.3389/fphar.2023.1155271

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Copyright © 2023 Quintás, Castell and Moreno-Torres.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Metabolite annotation. Several considerations should be accounted for besides accurate mass (AM) and retention time (RT). This includes elimination of background signals (Kennedy, 2002), deisotoping (Joseph, 2017), recognition of adduct peaks in spectra (Patti et al., 2012) and mass spectrometry/mass spectrometry (MS/MS) fragmentation pattern that is compared to in house or publicly available databases or internal standards, and the matching degree is estimated (Johnson et al., 2016). Figure adapted from (Kim and Kang, 2021).