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. 2023 May 5;14:1182454. doi: 10.3389/fimmu.2023.1182454

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Copyright © 2023 Vultaggio-Poma, Sanz, Amico, Violi, Ghisellini, Pizzicotti, Passaro, Papi, Libanore, Di Virgilio and Giuliani

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Blood sNLRP3 levels vary in different clinical conditions in COVID-19 patients. (A) patients with fever and respiratory symptoms at debut (n=42); (B) patients who required hospitalization in Pneumology division (n=38); (C) patients who required mechanical ventilation (n=25); (D) patients who required hospitalization in Intensive care unit (ICU) (n=10); (E) patients who died during hospitalization (n=10). Data are means ± SE (standard error). Comparisons between groups were performed using Mann-Whitney U test. A two-sided p-value ≤0.05 was considered statistically significant. sNLRP3: soluble nucleotide-binding oligomerization domain (NOD), leucine-rich repeat (LRR)-containing protein (NLRP) 3.