Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 May 19;8:204. doi: 10.1038/s41392-023-01468-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — The JAK-STAT signaling pathway and immune. Interactions between a large number of cytokines and the JAK-STAT pathway influence immune cell differentiation and development and exert immunoregulatory effects. IFN and IL-12 are crucial for Th1 cell differentiation and drive T-bet gene expression through STAT1 and STAT4, respectively. IL-4 upregulates GATA3 genes via STAT6 to activate Th2 cell differentiation. IL-6 and TGF play an essential role in Th17 cell differentiation via STAT3 to trigger RORt gene expression. IL-6 and IL-12 influence T follicular helper cell differentiation via STAT3 to increase Bcl-6 transcription. IL-2 induces Treg cell differentiation via the direct combination of STAT5A/B with the Foxp3 gene