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Schematic overview of the modeled drug–drug(−gene) interaction network. While tacrolimus acts as a CYP3A4 and CYP3A5 victim drug, voriconazole, itraconazole, and rifampicin represent CYP3A4 perpetrator drugs. Voriconazole and itraconazole additionally inhibit CYP3A5. For simplicity, the mechanism‐based inactivation of CYP3A4 and CYP3A5 by tacrolimus is not shown. CYP, cytochrome P450.
