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. 2023 May 5;4:1140778. doi: 10.3389/fpain.2023.1140778

Table 4.

Direct and indirect effects between gratitude and depression through social support and TNF-α.

Path Estimate 95% CI
Lower Upper
Total effect (c) −0.3072* −0.5225 −0.0920
Direct effect (c′) −0.1428 −0.3329 0.0473
a1 (Gratitude → Emotional Support) 0.3643* 0.0760 0.6526
a 2 (Gratitude → TNF-α) 0.0372 −0.0518 0.1262
b 1 (Emotional Support → TNF-α) 0.0295 −0.0523 0.1112
b 2 (Emotional Support → Depression) −0.4324* −0.6068 −0.2580
d 1 (TNF-α → Depression) −0.1446 −0.7473 0.4580
Indirect effects
a 1 b 2 −0.1575 −0.3596 0.0316
a 2 d 1 −0.0054 −0.0420 0.0268
a 1 b 1 d 1 −0.0016 −0.0175 0.0077
Total indirect effect −0.1645 −0.3679 0.0329
*

p < 0.05 is statistically significant.