Figure 2.

Functional network clusters in the Combined green gene list. Colour of node represents clustered GO functions, size of node represents significance of GO term. Functional clusters primarily centre around embryonic morphogenesis (shown in green), chromatin organization and remodelling (shown in red) and protein production and stability (shown in blue). Genes contributing to each function are shown in boxes to the side of the grouped functions. Gene names are split into three sections; the top section shows genes that were present in both the PA green gene list and the OxSOC green gene list, the middle section shows genes that were present in the PA green gene list but not the OxSOC green gene list, the bottom section shows genes that were present in the OxSOC green gene list but not the PA green gene list. Genes that were associated with moderate to severe forms of intellectual in OxSOC cases or in the literature or in HPO (https://hpo.jax.org/app/) under the terms ‘intellectual disability’ or ‘global developmental delay’ (moderate, severe or profound) are highlighted in bold.