Figure 2.
Epigenomic evolution of promoter methylation in synchrony with the molecular evolution of genes
(A) The boxplot shows the distribution of promoter methylation divergence values for ∼660,000 orthologous gene pairs with dS < 3, divided into six bins by dS values. The regression line with the 95% confidence interval demonstrates a significant correlation (p < 2.2 × 10−16) between promoter methylation divergence and dS of all gene pairs, indicating that gene pairs with larger dS values and higher evolutionary distances tended to differ in promoter methylation.
(B) The boxplot shows the distribution of mean promoter methylation levels for more than 10,000 genes, divided into five bins by dN/dS values. The regression line with the 95% confidence interval demonstrates a significant correlation (p < 2.2 × 10−16) between mean promoter methylation and dN/dS of all these genes, indicating that genes with lower evolutionary rates tend to have lower mean promoter methylation levels.