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Evolutionary origins of documented human and mouse ICRs
Arrows indicate that ICRs may arise during the evolution of the branch. Somatic ICRs are marked by an asterisk (“∗”), and the rest are germline ICRs. Two somatic ICRs (MEG3 and MEG8) are located within the imprinting cluster of the germline ICR DLK1-DIO3, and two others (NESPAS-GNASXL, GNAS1A) are located within the cluster of the germline ICR GNAS. The divergence time of each node was extracted from TimeTree.96
