Figure 2.
Maximal endothelial-dependent response and the role of oxidative stress. Maximal endothelial-dependent dilation to acetylcholine (ACh; 10−4M) during acute (30 min) incubation with xanthine oxidase (a), Tempol (b), and febuxostat (c). #p < 0.05 vs no incubation experiment within the same group; mean ± SD; n = 16–20 mouse MCA’s/group. Repeated measured ANOVA with a group-by-incubation interaction was performed and when a significant interaction (all panels) was established a tukey post-hoc test was explored.