Figure 6.

Locomotor and cognitive behavior with chronic stress. Open field test was used to measure locomotor behavior with total horizontal movements via beam breaks (fine and ambulatory combined) in the arena (a), and the number of vertical beam breaks (rearing; b). Spontaneous alternation Y-maze test was used to measure locomotor behavior (distance moved [C] and speed [D]) and working memory (e). Mean ± SD. n = 11–18 mice/group. *p ≤ 0.05 vs control. Two-way ANOVA with a group-by-drug interaction was performed and when a significant interaction (panel e) was established a tukey post-hoc test was explored.