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. 2023 Apr 29;13(8):2721–2733. doi: 10.7150/thno.83543

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In vivo anti-inflammation of Cu-TCPP-Mn nanozyme on cardiac I/R injury rat models. (A) The schematic of the study design. (B) Representative cine images of infarcted hearts in systolic and diastolic period collected from I/R injury rats scanned by a 9.4 T MRI. (C) EF calculated from 9.4 T MRI images after one week of treatments (n = 3-6 per group). (D) Representative Masson's trichrome-stained and (E) quantitative analysis of infarcted hearts in SD rats 4 weeks after treatment with PBS, Cu-TCPP, and Cu-TCPP-Mn. Data are presented as mean ± S.D. The comparisons between samples were operated by one-way ANOVA. * indicates P < 0.05; ** indicates P < 0.01; *** indicates P < 0.001; ns indicates P > 0.05 with no significance.