Fig. 1.

Effects of Evodia extracts on AP in hiPSC-CMs A, B Representative APs in control (blue lines) and after 5- or 30-minutes in the presence of EF6 (black lines) or EF7 (red lines). C, D Representative APs after 5- or 30-minutes incubation in EF₅ (purple lines). E, Changes in APD90 (in %) after 5 min incubation with indicated extracts plotted versus respective DHE concentrations of the extract. F, Changes in APD90 (in %) after 30 min incubation with indicated extracts plotted versus respective DHE concentrations of the extract. See Supplementary Table 14S for the rate corrected action potential duration (APDc). Number of datapoints in A-F = 4. Dotted line in F marks the 50% threshold to make the division into the low- intermediate- and high-arrhythmogenic categories. Extracts in A – F were applied at a concentration of 10 mg/ml.