REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
FAP	Abcam	ab207178; RRID: AB_2864720
BMI1	Abcam	ab126783; RRID: AB_11127730
ABCG2	Abcam	ab108312; RRID: AB_10861951
LMO7	Abcam	ab224113
MDR1	Cell Signaling Technology Inc	13342; RRID: AB_2631176
NANOG	Cell Signaling Technology Inc	4903; RRID: AB_10559205
MPRIP	Cell Signaling Technology Inc	14396; RRID: AB_2798472
YAP	Cell Signaling Technology Inc	14074; RRID: AB_2650491
pS397YAP	Cell Signaling Technology Inc	13619; RRID: AB_2650554
pS109YAP	Cell Signaling Technology Inc	46931; RRID: AB_2799315
KLF4	Cell Signaling Technology Inc	4038; RRID: AB_2265207
FAP	Santa Cruz Biotechnology	sc-65398; RRID: AB_831316
CD45	BD Biosciences	clone 30-F11; Cat# 557659, RRID: AB_396774
CD86	BD Biosciences	clone GL1; Cat# 560956, RRID: AB_10563076
CD206	BD Biosciences	clone MR5D3; Cat# 564668, RRID: AB_2738882
F4/80	BD Biosciences	clone T45-2342; 565410, RRID: AB_2687527
Bacterial and virus strains
LV-GV249/FAP/GFP	GeneChem Co., Ltd	N/A
LV-GV249/GFP	GeneChem Co., Ltd	N/A
Biological samples
Paraffin tissue section of CRC patients	Peking University Cancer Hospital & Institute	N/A
Critical commercial assays
CCK-8	Dojido	CK04
Bio-Rad SureBeads™ Magnetic Beads Kit	Bio-Rad	1614916
RhoA activation assay kit	Cytoskeleton	BK036
murine tumor dissociation kit	Miltenyi Biotec	130-095-929
Proteome Profiler Human Cytokine Array kit	R&D Systems, Inc.	ARY005B
Experimental models: Cell lines
HCT116	ATCC	CCL-247
HCT8	ATCC	CCL-244
LS174T	ATCC	CL-188
Experimental models: mouse
BALB/c-nu mice	Beijing HFK Bio-technology Co. Ltd	N/A
Oligonucleotides
GAPDH forward 5′- TGCACCACCAACTGCTTAGC-3′	Invitrogen	N/A
GAPDH reverse 5′- GGCATGGACTGTGGTCATGAG-3′¢	Invitrogen	N/A
FAP forward 5′- GGAAGTGCCTGTTCCAGCAATG -3′¢	Invitrogen	N/A
FAP reverse 5′- TGTCTGCCAGTCTTCCCTGAAG -3′¢	Invitrogen	N/A
BMI1 forward 5′- AGCAGCAATGACTGTGATGC-3′	Invitrogen	N/A
BMI1 reverse 5′-CAGTCTCAGGTATCAACCAG-3′	Invitrogen	N/A
ABCG2 forward 5′-CCTGGTGCTCCATGAGGAGAC-3′	Invitrogen	N/A
ABCG2 reverse 5′-CAGACTCTGACCTTTTGCCAGG-3′	Invitrogen	N/A
SOX2 forward 5′-ACATGAACGGCTGGAGCAAC-3′	Invitrogen	N/A
SOX2 reverse 5′-AGGAAGAGGTAACCACAGGG-3′	Invitrogen	N/A
OCT4 forward 5′-GACAACAATGAAAATCTTCAGGAGA-3′	Invitrogen	N/A
OCT4 reverse 5′-CTGGCGCCGGTTACAGAACCA-3′	Invitrogen	N/A
NANOG forward 5′-TGCCTCACACGGAGACTGTC-3′	Invitrogen	N/A
NANOG reverse 5′-TGCTATTCTTCGGCCAGTTG-3′	Invitrogen	N/A
CTNNB forward 5′-TGATGGAGTTGGACATGGCC-3′	Invitrogen	N/A
CTNNB reverse 5′-CTCATACAGGACTTGGGAGG-3′	Invitrogen	N/A
KLF4 forward 5′-AAGCCAAAGAGGGGAAGAC-3′	Invitrogen	N/A
KLF4 reverse 5′-CATCTGAGCGGGCGAATTTC-3′	Invitrogen	N/A
MDR-1 forward 5′-GCCTGGCAGCTGGAAGACAAATAC-3′	Invitrogen	N/A
MDR-1 reverse 5′-ATGGCCAAAATCACAAGGGTTAGC-3′	Invitrogen	N/A
ABCG2 forward 5′-GGAGGCCTTGGGATACTTTGAA-3′	Invitrogen	N/A
ABCG2 reverse 5′-GAGCTATAGAGGCCTGGGGATTAC-3′	Invitrogen	N/A
ALDH1 forward 5′-CGGGAAAAGCAATCTGAAGAGGG-3′	Invitrogen	N/A
ALDH1 reverse 5′-GATGCGGCTATACAACACTGGC-3′	Invitrogen	N/A
ALCAM forward 5′-TCCAGAACACGATGAGGCAGAC-3′	Invitrogen	N/A
ALCAM reverse 5′-GTAGACGACACCAGCAACAAGG-3′	Invitrogen	N/A
EPHB2 forward 5′-CGCCATCTATGTCTTCCAGGTG-3′	Invitrogen	N/A
EPHB2 reverse 5′-GATGAGTGGCAACTTCTCCTGG-3′	Invitrogen	N/A
siFAP5′-GAACAATATCCTAGAACAA dTdT -3′	RiboBio Co. Ltd.	N/A
siMPRIP5′-GACGGTTCTTCATCCTTTA dTdT -3′	RiboBio Co. Ltd.	N/A
Software and algorithms
GraphPad Prism 6.0 software	GraphPad Prism Software Inc.	https://www.graphpad.com/