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Surgical biopsy A: tumour composed of sheets of pleomorphic or spindle-shaped cells with eosinophilic cytoplasm and blurred cytoplasmic boundaries (inset: low-power whole-mount image); B: large and pleomorphic cells mixed with the spindle cell proliferation; C–G: immunohistochemistry: tumour cells are negative for PAX8 (C); positive for MyoD1 (D); Desmin (E); Myogenin (F); index of proliferation Ki67 estimated as 40 % (G).
