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Thyroidectomy. A: thyroid parenchyma totally fibrotic with rare small thyroid follicles enclosed within the fibrosis (inset: low-power whole-mount image); B: large pleomorphic cells with a large eosinophilic cytoplasm and large nuclei strongly nucleated with intra cellular eosinophilic filaments; immunohistochemistry: tumour cells are negative for PAX8 (C); positive for MyoD1 (D); Desmin (E); Myogenin (F); index of proliferation Ki67 estimated as 20 % (G).
