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. Author manuscript; available in PMC: 2023 May 19.
Published in final edited form as: Pediatr Blood Cancer. 2021 Aug 12;68(11):e29282. doi: 10.1002/pbc.29282

TABLE 3.

Dose-limiting toxicity (DLT)

Dose level Evaluable patients Patients with DLT DLT Attribution to protocol therapy
1a 12 2 Grade 3 elevated lipaseGrade 4 thrombocytopenia ProbablyPossibly
2 3 2 Grade 3 diarrheaGrade 3 hyponatremia DefinitelyPossibly
Dose level Age, years Evaluable patients Patients with DLT
1 < 12 6 0
≥ 12 6 2
2 < 12 0 0
≥ 12 3 2

Abbreviation: MTD, maximum tolerated dose.

a

17% of patients experience a DLT at the MTD.