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Lipid nanoparticle composition in the mRNA-1273 (Moderna) and BNT162b2 (BioNTech/Pfizer) vaccines [58]
| Vaccine | mRNA-1273 | BNT162b2 |
|---|---|---|
| Manufacturer | Moderna | BioNTech/Pfizer |
| mRNA dose, µg | 100 | 30 |
| Components | SM-102 | ALC-0315 |
| Distearoylphosphatidylcholine | Distearoylphosphatidylcholine | |
| Cholesterol | Cholesterol | |
| DMG-PEG2000 | ALC-0159 | |
| Ionizable cationic lipids : neutral lipids : cholesterol : PEGylated lipids (molar ratio, %) | 50 : 10 : 38.5 : 1.5 | 46.3 : 9.4 : 42.7 : 1.6 |
