Figure 6.

Cell viability studies of AcDEX, drug-loaded, TA-coated NPs, and curcumin on (A) human primary tenocytes and (B) KG-1 macrophages after 24 h of incubation. The concentrations of curcumin tested were calculated for each concentration of NPs taking into account the LD of the TA-coated NPs. Cell culture media and Triton-X 100 (1%) represented negative and positive controls, respectively. Results are presented as mean ± SD (n ≥ 3), and the samples were analyzed with ordinary two-way ANOVA, followed by a Dunnett post-hoc test, setting the probabilities at ***p < 0.001 and ****p < 0.0001, comparing all the samples to the negative control.