Table 2.

Univariable and multivariable MR analyses of BMI adjusted for hypertension, T2D, and FG as exposure and CKD or MA as outcome

Method	Β	SE	P	Egger intercept	P Egger	Cochran Q	Q df	PQ	I 2	F	OR (95% CI)
Univariable MR analysis (exposure: BMI, 446 SNPs; outcome: CKD)
MR-Egger	0.095	0.092	0.306	0.001	0.644	612.243	444	1.89E-07	27.480	97.437	1.099 (0.917, 1.317)
Weighted median	0.121	0.058	0.035							97.437	1.129 (1.008, 1.264)
IVW	0.134	0.036	1.64E-04			612.538	445	2.14E-07	27.351	97.437	1.143 (1.066, 1.226)
Simple mode	−0.125	0.162	0.440							97.437	0.882 (0.642, 1.213)
Weighted mode	0.078	0.098	0.427							97.437	1.081 (0.892, 1.308)
Multivariable MR analysis (exposure: BMI adjusted for hypertension and T2D, 340 SNPs; outcome: CKD)
IVW	0.124	0.049	0.011			575.703	380	3.31E-10	33.994	16.082	1.132 (1.028, 1.246)
Multivariable MR analysis (exposure: BMI adjusted for hypertension and FG, 167 SNPs; outcome: CKD)
IVW	−0.021	0.059	0.725			240.787	180	1.67E-03	25.245	12.119	0.980 (0.873, 1.099)
Univariable MR analysis (exposure: BMI, 441 SNPs; outcome: MA)
MR-Egger	0.477	0.182	0.009	−0.004	0.190	444.000	439	0.424	1.126	97.437	1.611 (1.127, 2.303)
Weighted median	0.340	0.122	0.005							97.437	1.405 (1.104, 1.786)
IVW	0.255	0.069	2.14E-04			445.741	440	0.415	1.288	97.437	1.291 (1.128, 1.478)
Simple mode	0.446	0.324	0.170							97.437	1.562 (0.827, 2.949)
Weighted mode	0.416	0.202	0.040							97.437	1.516 (1.020, 2.255)
Multivariable MR analysis (exposure: BMI adjusted for hypertension and T2D, 338 SNPs; outcome: MA)
IVW	0.141	0.090	0.117			383	378.000	0.418	1.318	16.232	1.151 (0.965, 1.372)
Multivariable MR analysis (exposure: BMI adjusted for hypertension and FG, 164 SNPs; outcome: MA)
IVW	0.194	0.110	0.080			168	177.000	0.675	−5.382	13.524	1.214 (0.977, 1.507)