Table 3.
Univariable and multivariable MR analyses of BMI adjusted for hypertension, T2D, and FG as exposure and UACR, eGFR defined using creatinine, and eGFR defined using cystatin C as continuous outcome
| Method | Β | SE | P | Egger intercept | P Egger | Cochran Q | Q df | PQ | I 2 | F | OR (95% CI) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariable MR analysis (exposure: BMI, 446 SNPs; outcome: UACR) | |||||||||||
| MR-Egger | 0.051 | 0.028 | 0.068 | −0.001 | 0.001 | 1,194.343 | 444 | 4.64E-70 | 62.825 | 97.437 | 1.052 (0.996, 1.111) |
| Weighted median | −0.027 | 0.012 | 0.029 | 97.437 | 0.973 (0.950, 0.997) | ||||||
| IVW | −0.031 | 0.011 | 0.004 | 1,221.872 | 445 | 1.23E-73 | 63.580 | 97.437 | 0.969 (0.949, 0.990) | ||
| Simple mode | −0.058 | 0.047 | 0.217 | 97.437 | 0.944 (0.861, 1.035) | ||||||
| Weighted mode | −0.038 | 0.032 | 0.236 | 97.437 | 0.962 (0.904, 1.025) | ||||||
| Multivariable MR analysis (exposure: BMI adjusted for hypertension and T2D, 340 SNPs; outcome: UACR) | |||||||||||
| IVW | −0.071 | 0.014 | 3.86E-07 | 969.480 | 380 | 3.53E-53 | 60.804 | 16.080 | 0.932 (0.907, 0.958) | ||
| Multivariable MR analysis (exposure: BMI adjusted for hypertension and FG, 167 SNPs; outcome: UACR) | |||||||||||
| IVW | −0.061 | 0.019 | 0.001 | 510.937 | 180 | 1.87E-33 | 64.771 | 12.119 | 0.941 (0.906, 0.976) | ||
| Univariable MR analysis (exposure: BMI, 446 SNPs; outcome: eGFR defined using creatinine) | |||||||||||
| MR Egger | 0.004 | 0.005 | 0.439 | 0.000 | 0.355 | 1,429.722 | 444 | 0.000 | 68.945 | 97.437 | 1.004 (0.994, 1.015) |
| Weighted median | 0.004 | 0.002 | 0.102 | 97.437 | 1.004 (0.999, 1.008) | ||||||
| IVW | −4.24E-04 | 0.002 | 0.835 | 1,432.480 | 445 | 0.000 | 68.935 | 97.437 | 1.000 (0.996, 1.004) | ||
| Simple mode | 0.008 | 0.008 | 0.345 | 97.437 | 1.008 (0.992, 1.024) | ||||||
| Weighted mode | 0.006 | 0.004 | 0.148 | 97.437 | 1.006 (0.998, 1.015 | ||||||
| Univariable MR analysis (exposure: BMI, 469 SNPs; outcome: eGFR defined using cystatin C) | |||||||||||
| MR Egger | −0.05 | 0.018 | 0.0014 | 0.00 | 0.04 | 1,334.57 | 444 | 2.36E-4 | 63.48 | 97.437 | |
| Weighted median | −0.06 | 0.01 | 1.09E-7 | 97.437 | |||||||
| IVW | −0.05 | 0.007 | 6.8E-16 | 1,384.91 | 445 | 2.41E-4 | 63.31 | 97.437 | |||
| Simple mode | −0.06 | 0.022 | 0.017 | 97.437 | |||||||
| Weighted mode | −0.06 | 0.016 | 0.0013 | 97.437 | |||||||
| Multivariable MR analysis (exposure: BMI adjusted for hypertension and T2D, 338 SNPs; outcome: eGFR defined using cystatin C) | |||||||||||
| IVW | −0.05 | 0.09 | 1E-8 | 1,288.98 | 380 | 6.44E-7 | 61.0 | 16.08 | 0.951 (0.797, 1.13) | ||
| Multivariable MR analysis (exposure: BMI adjusted for hypertension and FG, 152 SNPs; outcome: eGFR defined using cystatin C) | |||||||||||
| IVW | −0.03 | 0.12 | 0.014 | 1,093.29 | 6.45E-7 | 64.51 | 64.51 | 14.93 | 0.97 (0.767, 1.23) | ||