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. 2023 Apr 26;26(5):106774. doi: 10.1016/j.isci.2023.106774

Figure 3.

Figure 3

Gene expression signature specific to Tfh cells of TC origin

(A) Heatmaps for log2FC of significant DEGs (FDR-corrected p < 0.05) in each indicated comparison according to the color scale shown on the upper left. Genes were grouped by functional pathways indicated on the left of each cluster.

(B) Heatmaps for log2FC of protein levels of selected DEGs analyzed by flow cytometry. In (A) and (B), bold font indicates genes mentioned in the text.

(C) Flow cytometry analysis of SLAMF genes in non-Tfh and Tfh cells. Each symbol represents a mouse (n = 6–7) pooled from 2 experiments. Means ± s.e.m analyzed by 1-way ANOVA with Dunnett’s T3 multiple comparisons tests. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.