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. 2023 Apr 26;26(5):106774. doi: 10.1016/j.isci.2023.106774

Figure 4.

Figure 4

Lupus-susceptibility genes confer mitochondrial defects in Tfh and Tn cells

(A) GSEA plots on the indicated gene sets derived from the Molecular Signature Database. The inputs are ranked gene lists (Wald statistic) comparing separately TC and B6 Tfh cells on the left and Tn cells on the right. The asterisk associated with the FDR value for Glutathione metabolism indicates that this pathway did not meet the stringent significance threshold of FDR <0.05. However, it was modestly significant with the FDR control and shared similar gene-rank profiles with TC Tn versus B6 Tn.

(B) Heatmaps of log2FC for DEGs (FDR-corrected p < 0.05) in the gene sets shown in (A).