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. 2023 May 8;14(10):1845–1858. doi: 10.1021/acschemneuro.3c00074

Figure 4.

Figure 4

Effects of the systemic administration of standard S1R drugs (BD-1063 and PRE-084) and several experimental compounds in capsaicin-induced mechanical hypersensitivity in mice. (A) Effects of the subcutaneous (s.c.) administration of BD-1063, 8f and 5b on mechanical allodynia induced by the intraplantar (i.pl.) administration of capsaicin (1 μg), and absence of antiallodynic effects induced by 4b. (B) Effects of BD-1063, 8f and 5b administered alone and associated with the S1R agonist PRE-084. (C) Effect of BD-1063 alone and associated with 4b. Values are the mean ± standard error of the mean (SEM) obtained from six to nine animals per group: * p < 0.05, **p < 0.01 vs nonsensitized animals treated with the solvent of the drugs (black bar); #p < 0.05, ##p < 0.01 vs capsaicin-injected mice treated with the solvent of the drugs (white bar); +p < 0.05,++p < 0.01 selected doses of antiallodynic compounds associated with PRE-084 (B) or 4b (C), or their solvent (one-way analysis of variance (ANOVA) followed by Bonferroni test).