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. 2023 May 8;14(10):1845–1858. doi: 10.1021/acschemneuro.3c00074

Table 2. Affinities for Diazabicyclo[4.3.0]nonane Derivatives.

graphic file with name cn3c00074_0009.jpg

			K_i (nM) ± SD^a
compound	n	m	S1R	S2R	K_iS2R/K_iS1R
8a	0	0	254 ± 32	148 ± 29	0.6
8b	0	1	505 ± 88	279 ± 83	0.6
8c	1	1	19 ± 2.6	126 ± 19	6.6
8d	2	1	1726 ± 403	114 ± 15	0.07
8e	0	2	108 ± 31	91 ± 5.8	0.8
8f	1	2	10 ± 1.6	165 ± 36	16.5
8g	2	2	710 ± 150	1026 ± 200	1.4

^a

Each value is the mean ± SD of at least two experiments performed in duplicate.