Table 4. Ratio of Ki Values with or without Phenytoin in the S1R Radioligand Binding Assay.
compound | Ki (nM) control | Ki (nM) + phenythoin | ratio Ki (nM) control/+ phenythoin |
---|---|---|---|
4b | 3.2 | 1.2 | 2.6 |
5b | 12 | 14 | 0.9 |
8f | 9.6 | 12 | 0.8 |
SKF-10,047 | 99 | 17 | 5.8 |
BD-1063 | 6.7 | 10 | 0.7 |