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. 2023 May 8;14(10):1717–1763. doi: 10.1021/acschemneuro.3c00127

Table 5. Highlighted Clinical Trials Utilizing Probiotics for the Treatment of DGBI.

clinical trial identifier condition probiotic intervention status
NCT02592200485 functional constipation Lactobacillus gasseri DSM 27123 complete
NCT04304170486 functional constipation Bifidobacterium animalis lactis (LMG P-28145) complete
NCT04662957487 diarrhea-predominant irritable bowel syndrome Bifidobacterium breve BB010, Bifidobacterium longum BL020, Bifidobacterium bifidum BF030, Bifidobacterium lactis BL040, Lactobacillus rhamnosus LR110, Lactobacillus paracasei LPC100, Lactobacillus acidophilus LA120, Lactobacillus casei LC130, Lactobacillus plantarum LP140, Streptococcus thermophilus ST25 complete
NCT05566171488 functional constipation Bifidobacterium lactis CNCM I-2494, Bifidobacterium lactis DN 173-010 enrolling by invitation
NCT01463293489 functional constipation Bifidobacterium lactis HN019 complete
NCT01102036490 functional constipation Lactobacillus paracasei F19, Lactobacillus paracasei LA-5, Bifidobacterium lactis BB-12 complete
NCT03721107491 diarrhea- and constipation-predominant irritable bowel syndrome Blautia hydrogenotrophica complete
NCT00534170492 functional diarrhea Lactobacillus casei Shirota, Bifidobacterium breve Yakult complete
NCT00794924493 functional diarrhea, functional constipation Streptococcus thermophilus, Bifidobacterium breve, Bifidobacterium longum, Bifidobacterium infantis, Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus paracasei, Lactobacillus delbrueckii subsp. bulgaricus complete
NCT02213172494 irritable bowel syndrome Bifidobacterium longum R0175, Lactobacillus paracasei HA-196 complete
NCT00807326495 functional diarrhea Saccharomyces boulardii complete
NCT05054309496 irritable bowel syndrome Bifidobacterium longum NCC3001 recruiting
NCT01099696497 functional dyspepsia Bifidobacterium infantis 35624 complete
NCT01887834498 irritable bowel syndrome Lactobacillus gasseri, Bifidobacterium bifidum, Bifidobacterium longum complete
NCT04605783499 functional diarrhea Saccharomyces boulardii CNCM I-745 not yet recruiting
NCT04950296500 irritable bowel syndrome with diarrhea Lactobacillus plantarum UALp-05 complete
NCT05149599501 irritable bowel syndrome Saccharomyces cerevisiae complete