. 2023 Jun;51(6):700–717. doi: 10.1124/dmd.122.001010

Table 1.

Tissue expression patterns, genomic localization, and endogenous ligands of iLBPs

Gene	Protein Name	Molecular Weight (kDa)^a	Human Gene Locus^b	Tissue Expression	Known Endogenous Ligands
Subfamily I
RBP1	CRBP1	15.9	3q23	Adipose, brain, heart, kidney, liver, lung, mammary gland, muscle, ovary, pituitary, spinal cord, skin, spleen, stomach, testis	Retinol, retinaldehyde
RBP2	CRBP2	15.7	3q23	Heart, muscle, small intestine, placenta	Retinol, retinaldehyde, monoacylglycerols
RBP5	CRBP3	15.9	12p13.31	Adipose, heart, muscle	Retinol, retinaldehyde
RBP7	CRBP4	15.5	1p36.22	Large intestine, heart, kidney	Retinol, retinaldehyde
CRABP1	CRABP1	15.6	15q25.1	Adipose, adrenal, brain, eye, kidney, liver, lung, lymph nodes, muscle, pancreas, skin, small intestine, spleen, stomach, testis, thymus	Retinoic acid, retinoic acid metabolites
CRABP2	CRABP2	15.7	1q23.1	Skin, testis	Retinoic acid, retinoic acid metabolites
Subfamily II
FABP1	Liver FABP	14.2	2p11.2	Kidney, liver, lung, pancreas, small intestine, stomach	LCFAs, fatty acyl CoA, fatty acyl-carnitines, monoacylglycerols, lysophospholipids, bile acids, cholesterol, heme, bilirubin, retinoic acid, endocannabinoids, prostaglandins, vitamin K
FABP6	Ileal FABP	14.4	5q33.3	Adrenal, ovary, small intestine, stomach	Bile acids, LCFAs
Subfamily III
FABP2	Intestinal FABP	15.2	4q26	Small intestine, liver	LCFAs
Subfamily IV
FABP3	Heart FABP	14.9	1p35.2	Adipose, adrenal, brain, heart, kidney, liver, lung, mammary gland, muscle, ovary, placenta, spleen, stomach, testis	LCFAs, EETs, HETEs, DHETs
FABP4	Adipose FABP	14.7	8q21.13	Adipose, dendritic cells, macrophages, muscle	LCFAs, retinoic acid
FABP5	Epidermal FABP	15.2	8q21.13	Adipose, brain, dendritic cells, eye, heart, kidney, liver, lung, macrophages, mammary gland, muscle, placenta, skin, small intestine, spleen, stomach, testis, tongue	LCFAs, endocannabinoids, retinoic acid
FABP7	Brain FABP	14.9	6q22.31	Brain, central nervous, mammary gland, muscle, system glial cells, eye	LCFAs
FABP8	Myelin FABP	14.9	8q21.13	Peripheral nervous system myelin	Cholesterol, LCFAs
FABP9	Testis FABP	15.1	8q21.13	Mammary gland, salivary gland, testis	LCFAs
FABP12	FABP12	15.6	8q21.13	Retina, testis	LCFAs

^aMolecular weight determined by Expasy ProtParam (Gasteiger et al., 2005) based on reference amino acid sequence.

^bGene location obtained from the National Center of Biotechnology and Information gene database.

DHET, dihydroxyeicosatrienoic acids; EET, epoxyeicosatrienoic acid; HETE, hydroxyeicosatetraenoic acid.

References: Veerkamp and Zimmerman, 2001; Xueping et al., 2002; Pelsers et al., 2005; Schug et al., 2007; Liu et al., 2008; Storch and Corsico, 2008; Noiri et al., 2009; Rowland et al., 2009; Smathers and Petersen, 2011; Wang et al., 2014; Lee et al., 2015; Rezar et al., 2020.