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. 2023 May 19;25:83. doi: 10.1186/s13075-023-03066-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Comparison of the rs11583641 mQTL between synovium and cartilage. A The median DNA methylation value for each of the 12 CpGs stratified by genotype at rs11583641. B Heatmap showing the contribution of rs11583641 genotype to DNA methylation at the 12 CpGs. r² values calculated by linear regression and expressed as a percentage. C DNA methylation at each CpG stratified by tissue type and irrespective of genotype at rs11583641. P values were calculated by the Mann–Whitney U test