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[Preprint]. 2023 Nov 29:2023.05.05.539613. Originally published 2023 May 8. [Version 2] doi: 10.1101/2023.05.05.539613

Figure 3. The GGXXG and CV+C motifs are key determinants of CD4 function.

Figure 3.

(A, B) Representative IL-2 production is shown in response to a titration of MCC peptide from one experiment (left). Experiments were performed in triplicate and each symbol equals the mean +/− SEM at that peptide concentration. AUC analysis for the dose response is shown as a measure of the response magnitude for the average of three independent experiments performed with one independently generated set of cell lines (center). The average response to a low dose (41nM) of peptide is shown as a measure of sensitivity for three independent experiments performed with one independently generated set of cell lines (right). Results are representative of those obtained with at least three independently generated sets of cell lines. One-way ANOVA was performed with a Dunnett’s posttest for comparisons with WT and T1 samples, and a Sidak’s posttest for comparisons between selected samples.