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[Preprint]. 2023 Nov 29:2023.05.05.539613. Originally published 2023 May 8. [Version 2] doi: 10.1101/2023.05.05.539613

Table 1.

Motifs and mutants analyzed in this study.

Motif location/known function Mutant Names Mutated Motif Residue Mutations
C-terminally truncated CD4 T1 Ends at R422 R422 is the last residue
Extracellular D1 C”-strand (binds pMHCII) T1Δbind GKGVLIR K68D, V70D, L71S, I72D, R73S
TMD/Protein or cholesterol interactions T1-TMD GGxxG G403V, G406L
Juxtamembrane/Palmitoylation T1-Palm (2C) CV+C C418S, C421S
Juxtamembrane/Palmitoylation T1-Palm (3C) CCV+C C471S,C418S, C421S
TMD+Palm/raft localization T1-TP (2C) GGxxG, CV+C G403V, G406L, C418S, C421S
TMD+Palm/raft localization T1-TP (3C) GGxxG, CCV+C G403V, G406L, C417S, C418S, C421S