Table 3.

All values presented as percent of T1 control (mutant average/T1 average × 100) for normalized values.

Mutant Names	IL-2 magnitude	IL-2 sensitivity	Normalized pCD3ζ intensity	Normalized % Responders pCD3ζ	Normalized pZap70 intensity	Normalized % Responders pZap70	Normalized pPlcγ1 intensity	Normalized % Responders pPlcγ1	Lck DRM AUC	Lck Total AUC	Lck DSM AUC	CD4 expression	CD4 endocytosis
T1	100	100	100	100	100	100	100	100	100	100	100	100	100
Ti Δbind	1.53	0.00	54.86	91.39	71.96	111.9	74.32	106.8	ND	ND	ND	73.93	38.71
TMD	53.54	17.05	76.68	94.23	88.36	98.77	88.24	107.40	62.36	92.97	110.94	131.10	3.63
Palm (2C)	57.99	116.07	76.35	94.09	86.17	93.03	92.09	98.09	274.03	139.40	130.91	80.30	−98.00
TP (2C)	33.11	0.19	62.06	85.61	79.79	75.58	82.57	83.34	121.39	113.03	114.98	96.54	47.50
Palm (3C)	27.84	0.19	71.09	94.76	86.32	76.82	80.37	88.62	137.57	94.34	92.07	87.58	6.99
TP (3C)	31.19	45.53	62.49	84.60	80.16	66.92	70.91	82.81	86.84	101.20	102.74	79.59	−54.69