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[Preprint]. 2023 Nov 2:2023.05.09.539329. Originally published 2023 May 10. [Version 2] doi: 10.1101/2023.05.09.539329

PMC10197621.1; 2023 May 10
PMC10197621.2; 2023 Nov 2

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Figure 4: — Rare homozygous pLOF variants and “human knockouts” in RGC-ME

A. Distribution of the number of individuals per gene knockout on the log₁₀ scale

B. Breakdown of the number of putative gene KOs observed in RGC-ME by ancestry.

C. Projected accrual of putative gene KOs at hypothetical cohort sizes for each ancestral group in 1.01M related individuals. Curves reflect accrual of the expected number of genes with at least 1, 5, and 10 carriers, respectively, of a homozygous variant.