Table 2: Performance metrics for the GPS in ADPKD M1, M2, and M3 carriers and non-carriers in the meta-analysis of UKBB and AoU cohorts.

OR adjusted for age, sex, diabetes, PCs of ancestry, and genotyping array or batches; AUC was calculated for the full model (GPS and covariates) and for GPS alone without covariates (crude); variance explained was calculated for the GPS alone by estimating variance explained by the full model (GPS and covariates) minus the variance explained by the covariates-only model. P-values are two-sided and not corrected for multiple testing. CI: Confidence Intervals.

ADPKD variants	Cases/controls	OR (95% CI), P-value	AUC full model (95%CI)	AUC crude (95%CI)	Variance explained
Non-carrier
	21,901/275,638	1.72 (1.69–1.76), P<E-300	0.78 (0.78–0.78)	0.62 (0.62–0.62)	0.039
M1
	41/81	2.28 (1.55–3.37), P=2.6E-05	0.96 (0.92–1.00)	0.69 (0.59–0.79)	0.128
M2
	44/95	2.21 (1.37–3.58), P=3.3E-05	0.97 (0.93–1.00)	0.70 (0.60–0.80)	0.103
M3
	52/215	5.25 (2.31–11.9), P=7.4E-05	0.97 (0.94–1.00)	0.69 (0.60–0.78)	0.076