Table 2.
Clinical Outcomes, Endotypes, and Severity Predictions.
| Variable | Septic (N = 377)1 | At-Risk (N = 145)1 | p-value2 |
|---|---|---|---|
| Secondary Infection | 114 (30.2%) | 12 (8.3%) | < 0.001 |
| CCI | 122 (32.4%) | 10 (6.9%) | < 0.001 |
| Adverse Outcome | 213 (56.7%) | 40 (27.8%) | < 0.001 |
| Missing | 1 | 1 | |
| Poor Discharge Disposition | 152 (40.4%) | 23 (16%) | < 0.001 |
| Missing | 1 | 1 | |
| In-Hospital Mortality | 28 (7.4%) | 3 (2.1%) | 0.02 |
| 30-Day Mortality | 38 (10.2%) | 6 (4.1%) | 0.03 |
| Missing | 4 | 0 | |
| 90-Day Mortality | 61 (16.8%) | 8 (5.5%) | < 0.001 |
| Missing | 13 | 0 | |
| Endotype | < 0.001 | ||
| Adaptive | 151 (40.1%) | 74 (51%) | |
| Coagulopathic | 97 (25.7%) | 48 (33.1%) | |
| Inflammopathic | 129 (34.2%) | 23 (15.9%) | |
| IMX-SEV Severity | < 0.001 | ||
| Risk Band | |||
| Low | 38 (10.1%) | 16 (11 %) | |
| Moderate | 250 (66.3%) | 124 (85.5%) | |
| High | 89 (23.6%) | 5 (3.5%) |
1
n (%)
2
Pearson’s Chi-squared test
CCI: Chronic Critical Illness; Adverse Outcome is defined as cumulative incidence of in-hospital, 30- and 90-day mortality, development of CCI, and poor discharge disposition.