Extended Data Fig. 1 ∣. Gene expression profiling in longitudinally collected fibroblasts and corresponding reprogrammed MSNs.

a, Information of fibroblast samples used in the longitudinal study. b, RT-qPCR analysis of DARPP-32 expression in longitudinally aged MSNs. Statistical significance was determined using t-test; ***p<0.001, **p<0.01, and mean±s.e.m. c and d, Heatmap of Differentially Expressed Genes (DEGs) in fibroblasts (c) and MSNs (d) (FDR<0.05, ∣FC∣≥1.5). e, Venn diagram of the genes enriched in calcium signaling pathway from old HD-MSNs.