Table 3.
List of proteins differentially expressed in or on EVs derived from patient plasma. The proteins listed here are listed using the most up-to-date gene symbol, according to GeneCards, The Human Gene Database (genecards.org). The proteins listed in Figure 4 were compared groupwise, by NCI status against the NC. On the left column, are listed proteins which were found to be upregulated in both MND patients versus NC. In the middle column, are listed the two proteins found to be downregulated in MND patient plasma derived EVs, relative to NC. Lastly, on the right column are listed proteins observed to be downregulated in ANI patients, relative to No NCI.
| MND | ANI | |
|---|---|---|
| Upregulated | Downregulated | Downregulated |
| PELP1 | TLN2 | ALB |
| FGG | DLGAP1 | SERPINA1 |
| HBB | IGHM | |
| IGHV1-69-2 | APOA1 | |
| FGB | GC | |
| A2M | SLC12A3 | |
| HP | NNT | |
| IGKV2D-28 | TLN2 | |
| DLGAP1 | ||
| IGHA1 | ||
| IGKV3-20 | ||
| IGLV1-47 | ||
| FGA | ||
| APOC1 | ||
| LRIG1 | ||
| APCS | ||
| IGHV3-73 | ||
| C3 | ||
| TF | ||
| IGKC | ||
| MYO7A | ||
| UPB1 | ||
| ANKDD1A | ||
| IGKV3D-7 | ||