Table 3.

Hazard ratios (95% CI) of independent variables which are associated with death in patients with MTX toxicity

	Cox- Hazard ratio (95% CI)
	Univariate		Multivariate
	Hazard ratio (95% CI)	P-value	Hazard ratio (95% CI)	P-value
Leucovorin dosea	1.1 (0.4–2.9)	0.84
Age	1.0 (1.0–1.1)	0.97
Gender (male by female)	1.3 (0.5–3.3)	0.63
Duration of symptoms	0.9 (0.8–1.1)	0.43
Comorbidity (HT or DM)	0.5 (0.1–1.5)	0.45
Dose cumulative MTX	1.0 (0.98–1.0)	0.84
Hemoglobin at baseline	0.9 (0.7–1.2)	0.52
WBC nadir (× 10^9)	0.4 (0.2–1.0)	0.06	0.7(0.3–1.7)	0.39
WBC at baseline (× 10^9)	0.6 (0.3–1.1)	0.11
Platelet count at baseline (× 10^9)	1.0 (1.0–1.0)	0.97
Platelet count nadir (× 10^9)	1.0 (1.0–1.0)	0.29
Serum albumin at baseline	0.2 (0.1–0.7)	0.01*	0.3 (0.1–0.9)	0.03*
Creatinine at baseline	1.2 (1.0–1.5)	0.06	1.2 (0.9–1.5)	0.23
Bilirubin at baseline	1.1 (0.7 -1.7)	0.64

Abbreviations: MTX Methotrexate, WBC White blood count, WBC nadir Lowest WBC count after randomization

^a25 mg vs 15 mg

^*p < 0.05