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Participation of Set7/9 in regulation of PARP1 and p53 in the context of ROS response. (a) Set7/9 methylates PARP1 on K508 thereby facilitating its accumulation at the sites of DNA breaks and promoting its enzymatic activity towards its protein targets; (b) Set7/9 activates p53 by methylating it on K372 and thereby promoting MDM2 expression.
