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The effect of Set7/9-driven methylation of YAP on transcription of its target genes, CAT and MnSOD. Set7/9 methylates YAP at K494 that results in retention of YAP in the cytoplasm. Inhibiting Set7/9 using a small-molecule inhibitor (R)-PFI-2 prevents YAP methylation, restores its nuclear localization and stimulates expression of YAP target genes, CAT and MnSOD.
