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. 2023 May 5;10:1070433. doi: 10.3389/fmed.2023.1070433

Figure 1.

Figure 1

EDP1815 resolves Th1-driven inflammation in vivo. (A) In a DTH model, C57BL/6 mice were immunized with KLH and CFA on day 0 and challenged in the ear 4 weeks later with KLH. Mice were orally dosed for 5 days per week from the day after immunization through ear challenge with vehicle or EDP1815 (TCC-4.69E+09) or with dexamethasone systemically. Ear inflammation was measured 24 h post ear challenge. Data shown as change in ear thickness (n = 5 mice/group). (B) DTH model was set up as previously described. Mice were challenged in the ear 9 days after sensitization. Ear inflammation was measured 24 h post ear challenge. Data shown as change in ear thickness (n = 5 mice/group) for groups dosed with EDP1815 and other Prevotella strains (P. jejuni TCC-6.29E+09, P. melaninogenica TCC-2.48E+09). All experiments were performed twice. Data shown are representative and results are expressed as mean ± SEM. ****p < 0.0001, ns: not significant as determined by ordinary One-Way ANOVA.