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. 2023 May 5;10:1070433. doi: 10.3389/fmed.2023.1070433

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Copyright © 2023 Itano, Maslin, Ramani, Mehraei, Carpenter, Cormack, Saghari, Moerland, Troy, Caffry, Wardwell-Scott, Abel, McHale and Bodmer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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EDP1815 is protective in Th2 driven model of allergic inflammation. BALB/c mice were topically sensitized daily on the ear with 45 nM MC903 from day 1 to 14. Mice were dosed orally daily with vehicle or EDP1815 (TCC-3.13E+09). Ear inflammation was measured on day 14. (A) Change in ear thickness (n = 5 mice/group). (B) Upon termination of study, ears were homogenized, and protein levels of IL-4 and IL-31 were measured by MSD. All experiments were performed twice. Data shown are representative and results are expressed as mean ± SEM. *p < 0.05, ***p < 0.001, ****p < 0.0001 as determined by Ordinary one-way ANOVA.