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. 2023 May 5;10:1070433. doi: 10.3389/fmed.2023.1070433

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Copyright © 2023 Itano, Maslin, Ramani, Mehraei, Carpenter, Cormack, Saghari, Moerland, Troy, Caffry, Wardwell-Scott, Abel, McHale and Bodmer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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EDP1815 alleviates skin pathology Th17 model of cutaneous inflammation. BALB/c mice were topically treated with 5% imiquimod, a TLR7 agonist for 7 days on the back skin and ear. Mice were dosed orally daily from day 1 through 7 with vehicle, dexamethasone (1 mg/kg IP) or EDP1815 (TCC-3.13E+09). (A) Time course of change in ear inflammation over 7 days. (B) At termination, splenocytes were ex vivo re-stimulated with PMA/Ionomycin for 48 h. Protein levels of IL-17A was measured from supernatants by MSD. IL-17A protein levels were also measured in ear tissue homogenates. All experiments were performed twice. Data shown are representative and results are expressed as mean ± SEM. ***p < 0.001, ****p < 0.0001 as determined by Ordinary one-way ANOVA.